![]() rutaecarpa and its active components may be useful in influenza virus infection-related inflammatory disorders. Weici Tang & Gerhard Eisenbrand Chapter 54 Accesses 10 Citations Abstract Wuzhuyu, Fructus Evodiae, is the dry, nearly ripe fruits of Evodia rutaecarpa (Juss.) Benth., E. ![]() As an effective agent to suppress H1N1-induced chemokines production and block chemokine-attracted leukocytes recruitment, E. SpringerLink Chinese Drugs of Plant Origin pp 509514 Cite as Home Chinese Drugs of Plant Origin Chapter Evodia rutaecarpa (Juss.) Benth. In summary, three major alkaloids displayed different potentials for inhibiting chemokines secretion and subsequently cell migration, which could partially explain the activity of ER. Evo and Rut, but not DeHE, also had the ability to inhibit cell migration toward RANTES and MCP-1, respectively. In the macrophage recruitment assay, both RANTES and MCP-1 markedly evoked cell migration and this phenomenon was significantly suppressed by ER. This was mimicked by Evo and Rut, but not DeHE. ER also moderately and significantly inhibited H1N1-stimulated MCP-1 production in A549 cells. Three alkaloids, although to differing extents, all concentration dependent, inhibited H1N1-induced RANTES production with Evo consistently being the most potent among these active components. Although rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been reported to reduce the systemic exposure of caffeine, the mechanism of this. ![]() ![]() The results showed that ER was a potent inhibitor of RANTES secretion by H1N1-inoculated A549 cells (IC(50): 1.9 ± 0.4 μg ml(-1)). Rutaecartpine has a half-life of one hour, so you should feel its effects fairly quickly. rutaecarpa (ER) and three major quinazoline alkaloids dehydroevodiamine (DeHE), evodiamine (Evo) and rutaecarpine (Rut), isolated from ER were employed to study their inhibitory effects against influenza A virus (H1N1)-induced chemokines production in A549 lung epithelial cells as well as on chemokines-evoked cell recruitment in HL-60-differentiated macrophages. For the best results, Rutaecarpine should be taken in 100mg doses before bedtime. These results clearly suggest that rutaecarpine increases the metabolism of caffeine, theophylline, theobromine, and paraxanthine by inducing CYP1A2 and CYP2E1 in rats.Evodia rutaecarpa is commonly used as an anti-inflammatory herbal remedy in traditional Chinese medicine. Soothing Cucumber, energizing Caffeine and de-puffing Evodia Fruit all part of the easiest two steps to help keep your skin calm while waving buh-bye to. The significant induction of ethoxyresorufin O-deethylase, pentoxyresorufin O-depentylase, and p-nitrophenol hydroxylase strongly supported the decrease in caffeine and its major metabolites in plasma, as well as in urine. The mean clearance was 0.20 liters/kg/hr and the mean volume of distribution was 0.82 liters/kg. ![]() The areas under the curve of both caffeine and its three major metabolites (paraxanthine, theophylline, and theobromine) were significantly reduced by rutaecarpine, indicating that caffeine was rapidly converted into the desmethylated metabolites, and that those were also quickly transformed into further metabolites via the hydroxyl metabolites due to the remarkable induction of CYP1A2 and 2E1. The mean (n 4) distribution half-life was 0.2 hr and the mean elimination half-life was 3.8 hr. Plasma and urine were collected serially for up to 24 h and the plasma and urine concentrations of caffeine and its metabolites were measured, and compared with those in control rats. Following oral administration of 80 mg/kg rutaecarpine for three consecutive days, caffeine (20 mg/kg) was given orally. Evodia rutaecarpa is a tree native to Korea and China, and its fruit (hereafter referred to as Evodia) exhibits remarkable antitumour properties. We investigated the microsomal enzyme activity using hepatic S-9 fraction and the plasma concentration-time profiles and urinary excretion of caffeine and its major metabolites after an oral administration of caffeine in the presence and absence of rutaecarpine in rats. Nasopharyngeal carcinoma (NPC), a neoplasm of the head and neck, has high incidence and mortality rates in East and Southeast Asia. Although rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been reported to reduce the systemic exposure of caffeine, the mechanism of this phenomenon is unclear. Evodia is used for digestion problems including diarrhea, dysentery, nausea, vomiting, abdominal pain, gastroesophageal reflux disease (GERD), stomach ulcers, and lack of appetite. ![]()
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